Kadcyla adotrastuzumab emtansine dose, indications. Youll need to have adobe acrobat or abode reader installed to see or read pdf files. To see an instance of this type used in a code example, see the applying a policy to a pdf document using the java api quick start in programming with livecycle es4. Options after kadcyla for her2positive breast cancer. Get medical help right away if you develop symptoms of liver disease, including persistent nausea, severe. The search was limited to studies performed in humans and published in the english language. Highlights of prescribing information these highlights do not include all the information needed to use ferrlecit safely and effectively. Kadcyla is given as an intravenous infusion in 21day cycles while a patient is receiving kadcyla therapy, drugs containing ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole should be avoided. Kadcyla adotrastuzumab emtansine for injection, for intravenous use initial u. Kadcyla is used both for early breast cancer and for breast cancer that has spread to other parts of the body metastatic. If you only have the free reader, you can subscribe to the pdf pack service to combine files or download a 30day trial of acrobat xi pro.
Im new here to this forum and am part of my moms support team. This package simplifies the inclusion of external multipage pdf documents in. Patients using medicare, medicaid, medigap, veterans affairs va, department of defense dod, tricare or any other governmentfunded program to pay for their medications are not eligible. Prior authorization protocol kadcyla adotrastuzumab. Combine or merge files into a single pdf, adobe acrobat dc. Jan 03, 2019 kadcyla is for intravenous infusion only. We would like to make the coordination of systemic therapy at the provis clinic and your facility as easy and seamless as possible for both you and your patient. Kadcyla is used to treat her2positive breast cancer. Kuvan sapropterin dihydrochloride tablets, for oral use kuvan sapropterin dihydrochloride powder, for oral solution initial u.
Navelbine vinorelbine tartrate dose, indications, adverse. Trastuzumab emtansine has rarely caused very serious possibly fatal liver disease. The prescriber service form and the patient consent form are required for enrollment in genentech access solutions. Referrals to the genentech biooncology copay card kadcyla. The search was limited to studies performed in humans and. Kadcyla is used to treat her2positive breast cancer kadcyla is used both for early breast cancer and for breast cancer that has spread to other parts of the body metastatic. Serious infusion reactions occurred with the administration of erbitux in approximately 3% of patients in clinical trials, with fatal outcome reported in less than 1 in. Kadcyla adotrastuzumab emtansine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Trastuzumab herceptin trastuzumab, herzuma trastuzumabpkrb, kanjinti trastuzumabanns, ogivri trastuzumabdkst, ontruzant trastuzumabdttb, trazimera trastuzumabqyyp bolded medications are the preferred products these medications are included in this policy but are not available in the market as of yet.
Inserting pdf files into an existing pdf using adobe acrobat pro. A user cannot open an unsecured pdf document until the returned document is written to a pdf or doc file. When inserting pages, you can choose whether to insert an entire document or just. Kadcyla prices, coupons and patient assistance programs. Kadcyla adotrastuzumab emtansine is a her2targeted antibodydrug conjugate adc which contains the humanized antiher2 igg1, trastuzumab, covalently linked to the microtubule inhibitory drug dm1 a maytansine derivative via the stable thioether linker mcc 4nmaleimidomethyl cyclohexane1carboxylate. Her2positive breast cancer living beyond breast cancer. Tdm1 reduced the risk of death by 32 percent and improved median overall survival os by almost seven months compared with physicians choice of therapy in heavily pretreated patients with her2positive advanced breast cancer. Ferrlecit sodium ferric gluconate complex in sucrose injection, for intravenous use initial u. To see this method used in a code example that removes a policy from a pdf document, see the removing a policy from a pdf document using the java api quick start in programming with livecycle es4. With the target pdf document open, choose document insert pages. Applicable x x x x x x x 1page of 2 04242020 this policy does not apply to health plans or member categories that do not have pharmacy benefits, nor does it apply to medicare.
Use caution with these agents and consider recent major changes indications and usage 1. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for adrucil fluorouracil. Pregnancy should be avoided by females taking adotrastuzumab emtansine during therapy and for 7 months after the last dose. Medication order form kadcyla adotrastuzumabemtansine. Submission to the pharmaceutical benefits advisory committee. Nexmabtm, a sitespecific antibodydrug conjugation method by. Carefirst bluecross blueshield is the shared business name of carefirst of maryland, inc. Dailymed kadcyla adotrastuzumab emtansine injection. You can use documentmanager to secure documents with policies, remove security from documents secured with policies, and to obtain the licenses for policysecured documents.
Monitor hepatic function at baseline and prior to each dose. Kadcyla is a her2targeted antibody and microtubule inhibitor conjugate indicated, as a single agent, for. The nccn compendium is a derivative work of the nccn guidelines. If you have a multipage pdf from another division, you may need to extract some of the pages in order to insert them where they need to be. Highlights of prescribing information these highlights do not include all the information needed to use kuvan safely and effectively. Nexmabtm, a sitespecific antibodydrug conjugation method by utilizing ligandprotected cysteinecontaining motifs, and its application to herceptindrug conjugate figure 3. Jul 28, 2016 hello, just came back from our trip visiting the hallwang clinic in germany. The pdfpages package makes it easy to insert pages of external pdf documents without worrying about the print space. Besponsa inotuzumab ozogamicin rationale for inclusion in. Ixempra ixabepilone dosing and administration guide. Herceptin trastuzumab, herceptin hylecta trastuzumab. If you add a folder that contains files other than pdfs, the nonpdf files are not added.
Kadcyla adotrastuzumab emtansine rochegenentech launch date. The macro package hyperref can automatically insert pdfmarks for hyper text links. Hello, just came back from our trip visiting the hallwang clinic in germany. Add files directly to your pdf or link to files on the web. Jul 25, 2014 effective for dates of service on or after july 1, 2014, adotrastuzumab emtansine kadcyla, procedure code j9354, will be a benefit of the cshcn services program for clients of any age. Add a pdf to your office file office support microsoft office support. How to insert a pdf file into another pdf file using. Side effects of kadcyla adotrastuzumab emtansine injection. In the select file to insert dialog box, locate and. If youre looking to insert the contents of your pdf file into an office. Adotrastuzumab emtansine kadcyla procedure code j9354 to.
Highlights of prescribing information initial dose of 4 mg. Trastuzumab is a humanized igg1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, her2. Highlights of prescribing information these highlights do not include all the information needed to use torisel safely and effectively. Tell us what you think of the guide to understanding her2positive breast cancer. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for horizant gabapentin enacarbil. Kadcyla trastuzumab emtansine package leaflet l01xc14. You can resize the object, but you cant edit it after you insert it. Serious infusion reactions and cardiopulmonary arrest infusion reactions. Kadcyla adotrastuzumabemtansineinfusion at provis infusion clinic thank you for allowing provis to assist in your patients care. Kadcyla 100 mg injectable 502420088xx kadcyla 160 mg injectable 502420087xx vii. Any person who knowingly files a request for authorization of coverage of a medical procedure or service with the intent to injure, defraud or deceive any insurance company by providing materially false information or conceals material information for the purpose of misleading. Adotrastuzumab emtansine is used to treat a certain type of breast cancer that has spread to other parts of the body. Kadcyla adotrastuzumab emtansine is a new class of chemotherapy drug called an antibodydrug conjugate used to treat breast cancer. It is also used as additional treatment in patients with her2positive early breast.
Serious fetal harm can occur if adotrastuzumab emtansine is administered during pregnancy or within 7 months prior to conception. Submission to the pharmaceutical benefits advisory committee trastuzumab emtansine kadcyla 12 june 20 submission breast cancer network australia welcomes the opportunity to provide comment to the. Talk to your doctor or nurse before you are given kadcyla if. Torisel kit temsirolimus injection, for intravenous infusion only initial u. This kadcyla price guide is based on using the discount card which is accepted at most u. Kadcyla extends survival in heavily pretreated patients. Submission to the pharmaceutical benefits advisory. She is age 70 with advanced her2positive breast cancer liver and bone mets. Adotrastuzumab emtansine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. A onepage pdf is relatively simple to insert while the process for inserting.
Trastuzumab herceptin trastuzumab, herzuma trastuzumab. The genentech biooncology copay card is available only for commercially insured patients. Trastuzumab is produced by recombinant dna technology in a mammalian cell chinese hamster ovary culture which may contain the antibiotic gentamicin. Kadcyla adotrastuzumab emtansine is a member of the her2 inhibitors drug class and is commonly used for breast cancer and breast cancer metastatic. Kadcyla,as a single agent, is indicated for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a taxane, separately or in combination. Cvs caremark is an independent company that provides pharmacy benefit management services to carefirst and bluechoice members. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for adrucil fluorouracil skip to. Adotrastuzumab emtansine injection is used to treat her2positive metastatic breast cancer cancer that has spread in patients who have previously received other medicines eg, trastuzumab, taxane medicine that did not work well or whose cancer has returned during or within 6 months of completing treatment. Weve made enrollment simpler, faster and more intuitive with some key changes to our forms. Risk of hepatotoxicity, liver failure and death has occurred. Combining multiple pdf files in adobe acrobat nsaa. Prior authorization protocol kadcyla adotrastuzumab emtansine natl confidential and proprietary page 1. Note that market specific restrictions or transitionofcare benefit limitations may apply.
Uptodate, electronic clinical resource tool for physicians and patients that provides information on adult primary care and internal medicine, allergy and immunology, cardiovascular medicine, emergency medicine, endocrinology and diabetes, family medicine, gastroenterology and hepatology, hematology, infectious diseases, nephrology and. Nitro pro enables you to combine pages from multiple pdfs into a single file. Prior authorization protocol kadcyla adotrastuzumab emtansine. A literature search was performed on pubmedmedline 1966 to october 2014 using the search terms and kadcyla. Johns wort may decrease ixabepilone plasma concentrations unpredictably and should be avoided safety information. Kadcyla is a prescription medicine used as an adjuvant after surgery treatment for her2positive early breast cancer when the patient has taken neoadjuvant before surgery treatment including a taxane and trastuzumab herceptin and there is cancer remaining in the tissue removed during surgery. The product catalog provides you with a full listing of tevas brand and generic product lines. Kadcyla is a her2targeted antibody and microtubule inhibitor conjugate indicated, as a single agent, for the treatment of patients with her2positive, metastatic breast cancer who previously received trastuzumab and a taxane. Highlights of prescribing information initial dose of. Sep 30, 2019 trastuzumab is a humanized igg1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, her2.
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